CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022408
Disease: Arthropathy
Arthropathy 		0.040 Biomarker group BEFREE YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes. 12972480 2003
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.100 Biomarker disease BEFREE Yet the precise characterization of YKL-40 in dementia cases is missing. 29126445 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Xenotransplantation of tumor-derived mural-like cells (GSDCs) expressing YKL-40 in mice developed extensive and stable blood vessels covered with more GSDCs than those in YKL-40 gene knockdown tumors. 23665676 2014
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.070 AlteredExpression disease BEFREE Within the groups with normal glucose tolerance and type 2 diabetes, obesity subgroups showed no difference with respect to either plasma YKL-40 or adipose tissue YKL-40 mRNA levels. 18650368 2008
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.050 AlteredExpression disease BEFREE WHO grade 1, 2, 3, and 4 primary astrocytomas (210 patients) were evaluated for YKL-40 protein expression status in immunohistochemical analyses. 20499402 2010
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.100 Biomarker disease BEFREE While not significantly lower than the AD-Dementia group on YKL-40 and neurogranin, mismatches were also not significantly different from controls. 29959263 2018
CUI: C0497327
Disease: Dementia
Dementia 		0.100 Biomarker disease BEFREE While not significantly lower than the AD-Dementia group on YKL-40 and neurogranin, mismatches were also not significantly different from controls. 29959263 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 Biomarker disease BEFREE While not significantly lower than the AD-Dementia group on YKL-40 and neurogranin, mismatches were also not significantly different from controls. 29959263 2018
CUI: C0022568
Disease: Keratitis
Keratitis 		0.010 Biomarker disease BEFREE While C. albicans keratitis was more severe in the corneas treated with Chi3l1 small interfering RNA (siRNA), corneas treated with recombinant CHI3L1 before C. albicans inoculation had markedly ameliorated keratitis, reduced fungal load, and decreased polymorphonucleocyte (PMN) infiltration in an interleukin 13 receptor α2 (IL-13Rα2)-dependent manner. 26238714 2015
CUI: C1392786
Disease: Cognitive changes
Cognitive changes 		0.010 Biomarker phenotype BEFREE Whether and how Aβ and YKL-40 affect brain and cognitive changes in cognitively healthy older adults is still unknown. 28505968 2017
CUI: C0001311
Disease: Acute bronchiolitis
Acute bronchiolitis 		0.010 AlteredExpression disease BEFREE What is New: • Measuring serum YKL-40 levels might help distinguish exacerbation of PIBO from acute bronchiolitis in young children. 28567534 2017
CUI: C2919945
Disease: Cavernous Hemangioma of Brain
Cavernous Hemangioma of Brain 		0.010 AlteredExpression disease BEFREE Western blotting results analysis showed that YKL-40 protein expression was significantly higher in CCM endothelium (P < 0.05). 30948312 2019
CUI: C0017638
Disease: Glioma
Glioma 		0.400 AlteredExpression disease BEFREE Western blot analysis of glioma samples for YKL-40 protein levels revealed substantial elevation in approximately 65% of GBMs and undetectable levels in lower-grade gliomas (grade II and III) or normal brain tissue. 12154041 2002
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.010 Biomarker group BEFREE We used publicly available "omics" data to develop a molecular process model of CKD in diabetes and identified a representative parsimonious set of nine molecular biomarkers: chitinase 3-like protein 1, growth hormone 1, hepatocyte growth factor, matrix metalloproteinase (MMP) 2, MMP7, MMP8, MMP13, tyrosine kinase, and tumor necrosis factor receptor-1. 28077457 2017
CUI: C0497327
Disease: Dementia
Dementia 		0.100 Biomarker disease BEFREE We used immunoassays to measure conventional CSF markers of amyloid and tau pathology (amyloid beta (Aβ)1-42, total tau (T-tau), and phosphorylated tau (P-tau)) as well as amyloid processing (AβX-38, AβX-40, AβX-42, soluble amyloid precursor protein (sAPP)α, and sAPPβ), large fibre axonal degeneration (neurofilament light chain (NFL)), and neuroinflammation (YKL-40) in 245 patients with a variety of dementias and 30 controls. 29558979 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 Biomarker disease BEFREE We suggest that the g.-131(C > G) promoter polymorphism has a substantial impact on serum concentrations of YKL-40 in patients with RA and healthy subjects. 21714862 2011
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.040 Biomarker disease BEFREE We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients. 31001555 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 Biomarker group BEFREE We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients. 31001555 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.040 Biomarker phenotype BEFREE We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients. 31001555 2019
CUI: C0865800
Disease: asthma with copd
asthma with copd 		0.020 Biomarker disease BEFREE We sought to explore the plasma levels of biomarkers associated with asthma (periostin, TSLP and YKL-40), COPD (NGAL) and their possible correlation with lung function, the bronchodilator response and radiographic imaging in patients with asthma, COPD and with features of ACO. 29580282 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE We sought to explore the plasma levels of biomarkers associated with asthma (periostin, TSLP and YKL-40), COPD (NGAL) and their possible correlation with lung function, the bronchodilator response and radiographic imaging in patients with asthma, COPD and with features of ACO. 29580282 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-40 levels in the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) are associated with asthma in early childhood. 28739286 2018
CUI: C0428974
Disease: Supraventricular arrhythmia
Supraventricular arrhythmia 		0.010 Biomarker phenotype BEFREE We sought to assess YKL-40 in a wide spectrum of supraventricular arrhythmias besides AFib in comparison with other inflammatory markers. 28639986 2017
CUI: C0575157
Disease: Deformity of spine
Deformity of spine 		0.010 AlteredExpression disease BEFREE We showed that elevation of circulating YKL-40 levels was correlated with a reduction of spinal deformity progression risk. 30952886 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 AlteredExpression disease BEFREE We showed that CHI3L1 and CHI3L2 were significantly upregulated in sALS smokers compared to non-smokers. 28989002 2017